蛋白質(zhì)芯片

內(nèi)容概要

人類基因組大規(guī)模測(cè)序工作已經(jīng)完成，隨著以功能基因組學(xué)和蛋白質(zhì)組學(xué)為主要研究?jī)?nèi)容的后基因時(shí)代來(lái)臨，蛋白質(zhì)芯片作為檢測(cè)蛋白質(zhì)存在和運(yùn)動(dòng)變化的高效工具，將為本世紀(jì)的疾病診斷和治療、新藥開(kāi)發(fā)、分子生物學(xué)、航空航天、司法鑒定、食品衛(wèi)生及環(huán)境監(jiān)測(cè)等領(lǐng)域帶來(lái)一場(chǎng)革命。    生物芯片技術(shù)是一種高通量檢測(cè)技術(shù)，它包括基因芯片、蛋白質(zhì)芯片及芯片實(shí)驗(yàn)三大領(lǐng)域。蛋白質(zhì)芯片以蛋白質(zhì)代替DNA作為檢測(cè)目的物，此基因芯片更接近生命活動(dòng)的物質(zhì)層面，以直接測(cè)定蛋白質(zhì)的相對(duì)水平及與其他分子在交互作用情況，以定量化的方式反映基因的活動(dòng)情況，因而蛋白質(zhì)芯片有著比基因芯片更加直接的應(yīng)用前景。本書(shū)對(duì)蛋白質(zhì)芯片技術(shù)進(jìn)行了全面細(xì)致地闡述，包括技術(shù)原理、生產(chǎn)方法、表面化學(xué)、檢測(cè)策略以及抗原、抗體數(shù)據(jù)分析，同時(shí)全書(shū)圖文并茂，提供了許多生物學(xué)應(yīng)用實(shí)例及實(shí)驗(yàn)草案。    本書(shū)知識(shí)全面，內(nèi)容豐富，集合了蛋白質(zhì)芯片技術(shù)的基礎(chǔ)知識(shí)和前沿研究，實(shí)用性廣泛，可讀性強(qiáng)。適用于從事生物芯片研究開(kāi)發(fā)以及生物信息學(xué)、蛋白質(zhì)組學(xué)、基因組學(xué)、分子生物學(xué)、生物化學(xué)、細(xì)胞生物學(xué)、生物技術(shù)等相關(guān)研究領(lǐng)域的教學(xué)科研人員或技術(shù)人員參考使用，也可做為研究生教材。

書(shū)籍目錄

List of ContributorsPrefaceForewordChapter 1 Principles of Protein MicroarraysChapter 2 Novel strategies in Protein Microarray Generation and DetectionChapter 3 Practical Guide to Protein Microarrays:Assay Systems,Methods,and Algorithms.Chapter 4 Microarrays for the High-Throughput Analysis of Protein-Carbohydrate InteractionsChapter 5 Protein Microarrays:Principles and LimitationsChapter 6 System-Oriented Proteomics Using Protein-Domain MicroarraysChapter 7 colorimetric Microarray Assays for Rheumatoid Arthritis Using a Recombiant Proteome LibraryChapter 8 Academic and Commercial Aspects of Protein Microarray DevelopmentChapter 9 Analyzing Proteins and Protein Modifications with ArrayTubeTM Antiboody MicroarraysChapter 10 Non-Contact Dispensing for Protein MicroarraysChapter 11 High Speed,High Efficiency Protein Printing by BioLPTMChapter 12 Putting the Bio in Biochips:Capture Agents for Protein Microarray Expression Profiling PlatformsChapter 13 Protein Biochips for the Profiling of Allergen-Specific AntibodiesChapter 14 Solid Supports for Protein Microarrays and Related DevicesChapter 15 Protein Microarrays for Biosensor ApplicationsChapter 16 Technological Aspects of Protein Microarrays and NanoarraysChapter 17 Mege-Dense Nanoarrays:The Challenge of Novel Antibody Microarray FormatsChapter 18  INFINITITMSystem:An Automated Multiplexing Protein Microarray PlatformChapter 19 Protein Microarrays for Analysis of Antibody Responses in Animals and HumansChapteG 20 G-Protein Coupled Receptor Microarrays:A Versatile Tool for Drug DiscoveryChapter 21  Proteome-Scale Analysis of the immune Response Against Pathogenic MicroorganismsChapter 22 Development of Protein Microarrays for Drug DiscoveryChapter 23 Development and Applications of functional Protein MicroarraysChapter 24 Enabling Tools for Protein MicroarraysIndes

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