藥物化學

內(nèi)容概要

李紹順、周虎臣主編的《藥物化學(第2版英中雙語注解版)》是藥物化學專業(yè)唯一一本英中雙語教材。以英文編寫，加以中文注釋。
《藥物化學(第2版英中雙語注解版)》分為17章，前6章為總論部分，主要闡述藥物研發(fā)的基本理論和基本方法，內(nèi)容包括新藥研究中先導化合物的發(fā)現(xiàn)和結(jié)構(gòu)優(yōu)化、藥物與受體相互作用、酶及其抑制劑的基礎(chǔ)理論和應(yīng)用、藥物代謝的基本概念、前藥的設(shè)計及計算機輔助藥物設(shè)計的基礎(chǔ)知識。第7～17章為各論，按目前新藥研究的重點領(lǐng)域分類，主要內(nèi)容包括神經(jīng)系統(tǒng)藥物、鎮(zhèn)痛及麻醉藥、代謝綜合征治療藥、胃腸道系統(tǒng)藥物、心血管系統(tǒng)藥物、抗腫瘤、抗病毒、抗真菌、抗感染及免疫抗炎藥，重點講解各類藥物治療現(xiàn)狀、作用機制、結(jié)構(gòu)與活性關(guān)系，代表性藥物的合成路線設(shè)計、臨床應(yīng)用及藥物代謝的相關(guān)知識。

書籍目錄

第二版前言
第一版前言
1  Drug Discovery，Design and Development
  1.1  Drug Discovery
    1.1.1  A Drug Discovery without a Lead
    1.1.2  Lead Discovery
  1.2  Lead Modification
    1.2.1  Identification of the Active Part：The Pharmacophore
    1.2.2  Structure Modificatio to Increase Potency and the
Therapeutic Index
  1.3  New Drug Development
    1.3.1  General Process of New Drug Development
    1.3.2  Preclinical Development and Investigational New Drug
Application
  1.4  Problems
  本章重點內(nèi)容
2  Recepto
3  Enzymes and Enzyme Inhibition
4  Drug Metabolism
5  Prodrugs and Drug Delivery System
6  Computer Aided Drug Design
7  Central Nervous System Drugs
8  Analgesics and Anesthetics
9  Drugs for Metabolic Syndrome Treatment
10  Agents for Gastrointestinal Diseases
11  Cardiovascular Agents
12  Anticancer Agents
13  Antiviral Agents
14  Antifungal Agents
15  Antibacterials
16  Antiparasitic
17  Inflammatory Diseases and Noteroidal Anti-inflammatory
Drugs(NSAIDs)

章節(jié)摘錄

版權(quán)頁：   插圖：   3. 4  Irreversible Enzyme Inhibitors A competitive irreversible enzyme inhibitor, also known as an active-site directedirreversible inhibitor or an enzyme inactivator, is a compound whose structure is similar tothat of the substrate or product of the target enzyme and which generally forms a covalentbond to an active site residue. In the case of irreversible inhibition it is not necessary tosustain the inhibitor concentration to retain the enzyme-inhibitor interaction. Because this is anirreversible reaction, once the target enzyme has reacted with the irreversible inhibitor, thecomplex cannot dissociate, and, therefore, the enzyme remains inactive, even in the absenceof additional inhibitor. This effect could translate into the requirement for smaller and fewerdoses of the drug. Even though the target enzyme is destroyed by the irreversible inhibitor, itdoes not mean that only one dose of the drug would be sufficient to destroy the enzymepermanently. Yes, it destroys that copy of the enzyme permanently, but our genes areconstantly encoding more copies of proteins that diminish in concentration. As the enzymeloses activity, additional copies of the enzyme are synthesized, but this process can take hoursor even days. In some cases, however, particularly where genetic translation of the targetenzyme is slow, it may be safer to design reversible inhibitors whose effects can be controlledmore effectively by termination of their administration. The term irreversible is a loose one; either a very stable covalent bond or a labile bondmay be formed between the drug and the enzyme active site. As pointed out earlier, some tight-binding reversible inhibitors also are functionally irreversible.

編輯推薦

《藥物化學(英中雙語注解版)(第2版)》對第一版進行了修訂，增減了相關(guān)內(nèi)容，形式更緊湊，內(nèi)容更精練。介紹藥物研發(fā)的基本理論與方法，以及目前新藥研究重點領(lǐng)域的藥物治療現(xiàn)狀、藥物的作用機理、構(gòu)效關(guān)系等，并以代表性藥物作為案例進行講解。適合藥物化學專業(yè)的師生和專業(yè)技術(shù)人員使用。

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